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same day, pending verification of billing information and the shipping
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We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Vitamin D3 (cholecalciferol) in a 5,000 IU table. Provides a higher dose of vitamin D for more aggressive vitamin D supplementation. Recommended for patients with low 25(OH)D blood levels who need more than a physiological dose to replete their vitamin D levels.
Humans are designed to derive vitamin D via sun exposure and not from food. Unfortunately, sunshine-derived vitamin D is limited because most individuals spend 40 or more hours per week working indoors. We have also been scared out of the sun due to fear of skin cancer and most apply sunscreen which effectively blocks the body’s ability to produce vitamin D3. Consequently the vast majority of individuals do not have normal levels of serum 25(OH) D3, which is thought to best reflect vitamin D levels. The normal range is 32-100 ng/mL, and researchers argue that 40 to 70 ng/mL is optimal (1).
Vitamin D is produced in the body when sunshine strikes the skin and converts 7-dehydrocholesterol into previtamin D3, which is converted into cholecalciferol (vitamin D3). The liver converts vitamin D3 into 25(OH)D3 (calcidiol). Most cells are able to convert 25(OH)D3 into 1,25(OH)2D3 (calcitriol), which is most well-known for its modulatory influence on bone metabolism, parathyroid hormone activity, and intestinal calcium absorption. We now know that 1,25(OH)2D3 functions as a seco-steroid and influences some 1000 different genes (2). Vitamin D is involved in numerous bodily functions, such as the modulation of inflammation, immune function, blood sugar regulation, and cell proliferation (1,3,4).
Researchers have demonstrated that the recommended dietary intake of about 400 IU and the upper limit of 2000 IU too low (1). It is thought that approximately 4000 IU of vitamin D3 represents a physiological dose and 10,000 IU is proposed as the new upper limit (5). While these numbers seem high to some, it should be understood that 10,000 IU is a mere 250 microgram (mcg) or ¼ of a milligram (mg). Our ability to absorb supplemental vitamin D3 and replenish serum 25(OH)D levels are not uniform. While varying among individuals, on average for every 1000 IU of daily supplemental vitamin D3, we can expect about a 10 ng/ml increase in serum 25(OH)D over a 3-4 month period (1). As vitamin D increases intestinal absorption of calcium, supplemental vitamin D3 is contraindicated in patients with hypercalcemia. The human body tightly regulates serum calcium levels between 8.5-10.6 mg/dL. The following conditions are associated with hypercalcemia: primary hyperparathyroidism, certain cancers, granulomatous diseases such as sarcoidosis, hyperthyroidism, and thiazide diuretics.
In such patients, serum calcium and 25(OH) D3 need to be monitored on a regular basis. For those without hypercalcemic conditions, 150 ng/mL of 25(OH) D3 is often not associated with hypercalcemia, indicating that 32-100 ng/mL is a very safe range. Vitamin D toxicity is thought to occur when serum 25(OH) D3 levels reach 200 ng/mL.
Symptoms of hypercalcemia include: depression, anxiety, cognitive dysfunction, headaches, fatigue, polyuria, polydipsia, nocturia, constipation, abdominal pain, muscle weakness, musculoskeletal aches/pains, and bone fractures in the long term. Individuals with hypercalcemia will commonly indicate that sunshine tends to generate one or more of the symptoms of hypercalcemia. For the typical Caucasian individual, it takes approximately 20 minutes of midday summertime sun exposure for the skin to begin to turn pink, which is called an erythemic dose. Approximately 10,000 IU of vitamin D3 is produced in 20 minutes for the average Caucasian individual wearing a bathing suit. Thus, individuals who enjoy sun exposure and the process of getting a suntan are not likely to be hypercalcemic.
Fair-skinned individuals who sunburn easily need to determine their tolerable level of sun exposure, and apply sunscreen thereafter. Melanin in the skin reduces vitamin D production, so darker skinned individuals such as those from the East, Africa, South America, and the Islands, require longer periods of sun exposure to attain adequate serum levels of vitamin D, and so are particularly at risk of deficiency. In the absence of adequate sun exposure, vitamin D supplementation is considered a requirement. Everyone should have their serum 25(OH)D levels assessed as it appears to be a more important marker of human health/disease potential then serum cholesterol levels. Most chronic conditions are thought to be associated with low serum 25(OH)D levels, including type II diabetes, heart disease, hypertension, cancer, autoimmune diseases, depression, schizophrenia, polycystic ovarian syndrome, asthma, osteoporosis, periodontal disease, macular degeneration, uscle weakness, osteoarthritis, fibromyalgia, and generalized pains in muscle, joint, and bone (1,3,4). For those without a chronic condition, it is important understand that vitamin D levels influence our daily lives in fashions that patients may not typically consider. For example, vitamin D adequacy is related to feelings of wellbeing (1). Physical activity issues are related to adequate vitamin D levels including exercise performance and propensity to fall in the elderly (1,6). Even resistance to upper respiratory tract infections (4) and the flu (2) are associated with adequate levels of vitamin D.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
One tablet provides amount
Vitamin D3 (cholecalciferol) ..................................5000 IU 1250%
Take ½ to 2 tablets per day with meals or as a directed by your health professional.
Store in a cool dry place and keep out of reach of children.
Clinical D3 5,000 IU 60 Vegetarian Microtabs
5 Stars based on 3 Review(s)
I would recommend this item to a friend.
Clinical D3 5,000 60 Vegetarian Microtabs
February 15, 2013
Great value for Clinical D3. Number of pills vs the cost.
Small, easy to swallow
I would recommend this item to a friend.
Clinical D3 5,000 microtabs
January 20, 2013
I have just started using Clinical D3.
I love it because they are very small tables.
I would recommend this item to a friend.
Best Clinical D3 Out There
January 3, 2013
I was diagnosed with very low vitamin D level (17) and Doctor told me to take some over the counter. i know how ineffective those can be so I talked to my chiropractor and she recommended anabolic labs Clinical D3 - 5,000IU. I went back to the Doc for a blood check and he thought I said I was taking 50,000IU because my numbers had improved so much. He then told me to keep taking what I was taking because it was working; my body was getting everything it could from these little pills. I will definitely be ordering this product again.
Size of the pill; only have to take one to get the dosage needed; cost compared to other "good" D3 supplements
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).