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Science-based nutrition Dietary supplement Modulates immune system function Promotes optimal immune health and wellness Powerful immune support
Daily Immune Defense featuring Epicor® contains three novel factors that powerfully support immune health and wellness. Epicor® is a nutritive dried yeast fermentate of Saccharomyces cerevisiae (used in baking and brewing) that supports cellular metabolism and modulates immune function. In vitro lab data has shown that Epicor® activates Natural Killer (NK) cells. Emed-OLE™ is a premier extract of olive leaf that has a high concentration of oleuropein, a powerful phyto-antioxidant that has shown an ability to regulate immune function. Immunolin® is a high quality purified protein isolate high in immunoglobulins and beneficial growth factors that are known to support immune system wellness.
Daily Immune Defense featuring EpiCor® also contains 2000 IU of vitamin D3 and 30 mg of zinc per daily dose. Vitamin D3 is known to powerfully modulate immune function and the activity of immune cells, and promote innate immunity. Zinc promotes immune wellness by supporting the body’s T-cell response and enhancing the body’s immune resistance. Copper is included to maintain a healthy zinc-copper ratio, as each mineral competes with the other for absorption. A proper balance of the two is important for health.
EpiCor® is a nutritive dried yeast fermentate of Saccharomyces cerevisiae (often used in baking and brewing) that supports cellular metabolism and modulates immune function. In vitro laboratory data has shown that EpiCor® activates Natural Killer (NK) cells.
EpiCor® is a unique and novel dietary supplement used for support of immune health,with a fascinating history of discovery. In 1943, a company in Cedar Rapids, Iowa began manufacturing and selling a fermentation product from the yeast Saccharomyces cerevisiae, the same yeast used in bread and beer making. The product was and still is used as an additive for animal feed to help improve digestion as well as overall health in animals. It has been on the market for over 60 years.
Interestingly, when the company became self-insured, they became aware of unusually low rates of illness in employees that worked in the manufacturing plant for this animal product.This led to very low increases in their insurance premiums over the years compared to other companies, saving them quite a lot of money. Hence they began to investigate what might be the cause of the “healthfulness”of the employees at the fermentation plant. This investigation and subsequent research studies led to the production of EpiCor® as a supplement for humans to support immune system health.
A comparison study was performed on blood from 10 fermentation plant workers compared to that from 10 age- and gender-matched controls. The fermentation plant workers had several immune cell parameters that appeared superior to the control group.These included decreased levels of CD8 cells resulting in significantly increased CD4 to CD8 ratios, significantly improved cytotoxic natural killer (NK) cell activity even though total NK cells were decreased in number, higher killing efficiency of NK cells, significantly increased levels of secretory IgA, increased numbers of EpiCor® specific antibodies, higher levels of red blood cell intracellular glutathione, and significantly lower levels of immune complexes.These results represent benefits on various cellular players of both the specific and innate parts of the immune system.
NK cells are one of the first lines of defense used by the immune system.An in vitro study performed on human cells showed that NK cells were activated after incubation with EpiCor®, as evaluated by expression of the CD69 activation marker.The CD25 marker (IL-2 receptor) was also induced in the NK cells, although to a lesser degree B cell activation was also noted through increased expression of CD80 and CD86 markers. Immediate increases in calcium levels were evident in peripheral blood mononuclear cells after exposure to EpiCor®, suggesting increased activation through calcium regulation.
Several human clinical trials have been performed to date using EpiCor® for supporting various aspects of the human immune response.30 The results of these studies attest to the multitude of potential benefits of EpiCor® supplementation. EpiCor® has been found to have a number of short-term effects, such as an increase in white blood cell activity, including an increase in NK cell activity and numbers. EpiCor® also possesses several long-term beneficial immune effects including enhancing healthy secretion of secretory IgA, which is an important part of the body's first line immune defense. By displaying both short and long-term immune potentiating benefits, EpiCor® is an ideal daily supplemental nutrient for supporting important aspects of immune health.
Emed-OLE™ is a premier extract of olive leaf that has a high concentration of oleuropein, a powerful phyto-antioxidant that has shown an ability to regulate immune function.
The bitter secoiridoid oleuropein is the major phenol component found in olive leaves, and is known for its antioxidant effects.The concentration of oleuropein in leaves by weight ranges from 9.04 to 14.32%.6 Other important constituents in the plant include oleuroside, ligstroside, demethyoleuropein, oleacin, kaempferol, quercitin, caffeic acid,erythrodiol, rutin, verbascoside, luteolin 7-glucoside, and apigenin 7-glucoside. A number of in vitro studies have established the antioxidant effects of oleuropein. In an in vivo model, rabbits fed oleuropein were found to have significantly lower levels of the oxidative stress marker malondialdehyde (MDA) in both plasma and in erythrocytes when compared to control rabbits. Additionally, a human study found that oral intake of increasing amounts of oleuropein and its hydrolysis derivative hydroxytyrosol led to significant dosedependant decreases of the oxidative stress marker isoprostane in the urine of the subjects.
Emed-OLETM is produced by Euromed from Olea europaea (Olive) trees found in the Andalusia region of southern Spain,which have been cultivated there since Roman times. The trees are grown under good agricultural practice (GAP) requirements prohibiting the use of herbicides, pesticides and fungicides on the tree during cultivation.The production utilizes a standardized method of water/ethanol extraction resulting in a full complement of fat and water-soluble olive phytochemicals. Extracts are carefully monitored to ensure the absence of contaminants as well as accurate and consistent levels of oleuropein in every batch. The drying process is performed in such a way to ensure that antioxidant activity is preserved. Emed-OLETM satisfies international monograph requirements for quality and safety.
Recent research on olive leaf extract highlights its potential immune-enhancing effects. Studies suggest that olive leaf extract supports a balanced immune response by modulating the production of several chemical messengers, or cytokines. For example, a recent animal trial found that administration of olive leaf extract led to a reduction in the release of inflammatory cytokines, including IFN- ? and IL-17. This action led to support of tissue health and an overall maintenance of healthy immunity.
Further results from in vitro trials have indicated gastrointestinal health-supportive properties of olive leaf extract and its derivatives. Oleuropein and elenolic acid from olive leaf extract have been shown to be effective promoters and regulators of microbial flora in the digestive tract and supporters of gut mucosal immunity.
Immunolin® is a high quality purified protein isolate high in immunoglobulins and beneficial growth factors that are known to support immune system wellness.
Immunolin® is a concentrated source of bovine immunoglobulins or antibodies, which are proteins that function as an important part of the adaptive immune system. Immunolin® is especially rich in particular classes of immunoglobulins,namely IgG, IgM,and IgA.When taken orally Immunolin® is intended to support and supplement the body's healthy immune system. In addition to immunoglobulins, Immunolin® also contains a number of other supportive constituents including transferrin, cytokines, endotoxin-binding proteins, and acute phase proteins. Plasma protein from which Immunolin® is derived has been commonly added to diets of early-weaned pigs in a spray-dried form in place of soy protein because it has been found to increase growth rate and food intake in these young and vulnerable animals in numerous studies. In one such study, a diet containing spraydried animal plasma was compared to a control diet in newly-weaned pigs and it was found that, although the mean daily protein intake did not differ between groups, the rate of weight gain and dietary protein conversion efficiency, as well as utilization for lean tissue growth,was significantly higher in the animals eating the plasma diet. Similarly, gain-to-feed ratios increased linearly in male newlyweaned mice fed diets with similar nutrient concentrations and increasing amounts of plasma protein.
To determine which component of the plasma protein provides its beneficial effects on growth performance, various molecular weight extracts of the plasma were compared.Pigs fed fractions especially rich in IgG produced similar beneficial results on growth and food intake increases as the plasma protein when compared to control diets. However, neither albumin-rich nor low molecular weight fractions produced such effects, suggesting that the IgG-rich fraction may be the important component from the plasma for the noted growth benefit. It has been hypothesized based on results discussed below that this benefit on growth may be due to a supportive effect on the immune system of these animals.
A number of animal studies have been performed using oral supplementation of plasma protein in healthy animals before and during immune system challenges. Findings show that healthy newlyweaned pigs fed spray dried plasma had improved growth performance, decreased IgA secretion, enhanced intestinal mucosal function, and decreased levels of certain cytokines including TNF-alpha and IL-8 after challenge compared to those fed a control diet. In addition to an increase in healthy weight gain and gain to feed ratios, nonchallenged pigs fed spray dried plasma protein had significantly lower percentages of macrophages, B lymphocytes, and gamma delta TCR positive lymphocytes in their lymph nodes and significantly lower percentage of macrophages in the Peyer's patches (important lymphoid components of the intestinal immune system) compared to controls.
An additional study looked at the effects of both animal plasma as well as concentrated immunoglobulins on the barrier function of the intestines in rats. Newly-weaned Wistar Lewis rats were fed either a control diet, a spray dried animal plasma enriched diet, or an immunoglobulin concentrate enriched diet. After challenge, the rats fed the control diet exhibited an increased permeability of the intestinal tract, while this was not seen in rats fed either the plasma protein or the immunoglobulin supplemented diets, suggesting a supportive role for these diets. Spray dried animal plasma also appears to have a positive effect on the growth of the beneficial bacteria Lactobacilli species in the intestinal tract of challenged pigs.
The production of Immunolin® for support of the immune system utilizes cold processing and low temperature drying of serum to ensure high quality and prevent any degradation of protein during the manufacturing process.
Vitamin D3 is a lipid-soluble vitamin that is known to beneficially modulate aspects of the immune system.
Vitamin D receptors are found on immune cells such as monocytes and lymphocytes. Activation of these receptors by the active form of vitamin D induces the transcription, proliferation and differentiation of immune cells. Vitamin D's effect on the immune system is multifactorial and not completely understood.However, it is known that vitamin D interacts with T cells, which are important white blood cells specific to the immune system. Among other actions, vitamin D has been shown to inhibit T-cell proliferation and CD8 T-cell mediated cytotoxicity in vitro. More specifically, vitamin D modulates the function of a subset of T cells, Th1 and Th2. It inhibits Th1 cell expression of the pro-inflammatory cytokines, IL-2 and IFN-?. These cells enhance cell-mediated immunity and phagocyte-dependent inflammation. On the other hand, vitamin D promotes the action of Th2 cells, which stimulate strong antibody responses, but inhibit inflammation. Thus, vitamin D balances these two important immune system functions, promoting a balanced immune response. Ensuring optimal vitamin D status may, therefore, support a healthy immune system by promoting a normal balanced inflammatory response.
In a recent trial, individuals were given various doses of vitamin D3 over a six-week period to assess its effect on immune function. Three distinct doses were administered: 800, 1600, or 2400 IU/day. The results of the study showed that all of the doses were effective in reducing the levels of CD34+ cells, which decrease immune function.The highest dose given, 2400 IU/day,was also shown to significantly increase the ability of T cells (innate immune cells) to mature. These findings indicate the importance of vitamin D for a healthy,well-functioning immune system.
Zinc is an essential trace mineral that is known to be critical for immune system wellness.
Zinc deficiency is known to significantly impact human immunological function. Like vitamin D, zinc's effects on the immune system are complex. Both T and B cells require zinc for proliferation. Affecting both innate and adaptive immunity, zinc plays the role of a signaling ion.This mechanism allows zinc to be involved in immune cell signal transduction, and therefore, almost all aspects of cellular immunity. Recent studies highlight the role of zinc for immune wellness.As an example, immunological status was assessed in 39 healthy, elderly individuals after being supplemented with zinc for 48 days. It appeared that zinc supplementation modulated inflammatory cytokine production, as well as immune cell function. One of the major findings in this study was that zinc was able to increase natural killer (NK) cell activity, an important part of the innate immune system in humans.
Further studies show that zinc supplementation benefits immune function in children as well as adults. In a particular study, zinc administered at a dose of 30 mg per day in children was shown to significantly enhance their immune defenses. This phenomenon has also been seen in an elderly population, where a lower baseline of zinc status was associated with decreased immunity. Once again, it appears that zinc supplementation can play an important role in supporting immune health in the young and elderly.
Adding to zinc's effects on immune wellness in the elderly,another placebo-controlled trial showed that zinc supplementation demonstrated antioxidant capabilites, supported a strengthened immune response and promoted a healthy inflammatory balance. After one year of supplementing with 15 mg of zinc,markers of oxidative stress (lipid peroxidation by-products, MDA, HAE and 8-oHdG) were significantly decreased in the zinc-supplemented group compared to placebo. Furthermore, zinc supplementation modulated the production of certain inflammatory cytokines.These results indicate that zinc may have additional benefits for immune health via its potential antioxidant and inflammatory balancing effects.
Daily Immune Defense featuring EpiCor® contains a combination of synergistic nutrients that have been well-studied for their ability to promote a healthy immune response and enhance the body's ability to defend itself and remain vigilant on a daily basis.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 2 capsules Servings per container: 60 servings
Amount Per Serving %DV
Vitamin D (as cholecalciferol)(D3) 1000 IU 250% ------------------------------------------------------------------------------------------ Zinc (elemental, as zinc gluconate) 15 mg 100% ------------------------------------------------------------------------------------------ Copper (elemental, as copper gluconate) 1 mg 50% ------------------------------------------------------------------------------------------ Immunolin® 500 mg † (containing a minimum of 45% IgG) ------------------------------------------------------------------------------------------ EpiCor® dried yeast fermentate 250 mg † ------------------------------------------------------------------------------------------ Emed-OLE™ Olive Leaf Extract 250 mg † (containing a minimum of 20% oleuropein) ------------------------------------------------------------------------------------------ † Daily Value not established
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).