MFG # 55122
UPC # 716963551229
Official Website: http://www.physiologics.com
Promotes Healthy Estrogen Metabolism
Dietary Supplement
More Info:
Laboratory Tested To Guarantee Quality
For Health Care Professional Use Only
HOW PATIENTS MAY BENEFIT
-Patented formulation designed to promote healthy estrogen metabolism
-Stabilized, bioavailable form of Diindolylmethane (DIM®)
PRODUCT DISCUSSION
PhysioLogics DIM (bioavailable 3,3-Diindolylmethane) is a patented, stabilized formula that helps promote cellular health and supports the enzymatic basis of healthy estrogen metabolism.
STRUCTURE AND FUNCTION
The compound 3,3-Diindolylmethane is a dietary indole which occurs naturally in Brassica vegetables. Brassica vegetables are also known as cruciferous vegetables and include broccoli, cauliflower, cabbage, turnips, kale and brussels sprouts. These vegetables are considered by many scientists to be among the most metabolically healthful foods because of their unique profile of naturally occurring biochemicals. Diindolylmethane is a stable dimer (double molecule) of indole-3-carbinol (I3C), which is generated upon hydrolysis of glucobrassicin, the indole glucosinolate in Brassica vegetables. Dehydration of I3C results in a mixture of oligomeric products, including diindolylmethane. Diindolylmethane has been shown to have beneficial enzymatic interactions in vitro, which is believed to help mediate its positive effects on estrogen metabolism.
CLINICAL EVIDENCE
A randomized, double-blind, placebo controlled, clinical study analyzed healthy estrogen metabolism in 20 postmenopausal women. Subjects were given either 108 mg/day of Diindolylmethane as DIM® or a placebo. DIM® treated subjects showed a significant increase in levels of 2-hydroxyestrone (p=0.020) and diindolylmethane (p=0.045), and an increase of 47% in the 2-hydroxyestrone/16-alpha hydroxyestrone ratio (p=0.059). Based on these results, the authors concluded that DIM® had positive effects on estrogen metabolite ratios. (Dalessandri et al, 2004)
In a double-blind, placebo-controlled, crossover study, 33 subjects received 60 mg of DIM® or placebo per day in four divided doses. Each study period lasted three months. At three months, a significant positive effect was observed on estrogen metabolism in the treatment group. No significant effect was observed in the placebo group. (Zeligs et al, 2005)
SUMMARY
PhysioLogics DIM® utilizes BioResponse-DIM®, a bioavailable form of Diindolylmethane, that helps promote healthy estrogen metabolism and cellular health.
PRODUCT BENEFITS:
As an Indole, diindolylmethane is a natural constituent of plants, particularly cruciferous vegetables. This bioavailable, patented form promotes healthy estrogen metabolism for women and cellular health.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
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