Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Homocystrol™ + TMG‚ provided by Douglas Laboratories‚ contains significant amounts of activated B vitamins‚ trimethylglycine (betaine) and choline needed for proper metabolism of homocysteine‚ and the support of metabolic synthetic processes requiring methyl donors.
Revised Formulation Homocystrol™ + TMG now provides bioavailable forms of B vitamins. Methylcobalamin‚ methylfolate‚ pyridoxal-5-phosphate‚ and riboflavin-5-phosphate are the forms most readily used by the body and do not require conversion once consumed.
FUNCTIONS Homocysteinemia‚ or elevated plasma homocysteine‚ is a major factor that can influence poor cardiovascular health. High plasma levels of homocysteine appear to have negative effects on the vasculature‚ impairing the functional abilities of endothelial and smooth muscle cells. Suboptimal intake of several B vitamins‚ renal failure‚ environment‚ diet‚ stress‚ and genetic defects in homocysteine metabolism can all contribute to abnormal homocysteine levels.
Homocysteine is a sulfur containing amino acid that is created in the body from methionine‚ an essential amino acid derived solely from dietary intake. Methionine is metabolized into homocysteine via an intermediate‚ Sadenosylmethionine. Homocysteine can be metabolized to produce cysteine‚ a nonessential sulfur-containing amino acid‚ or it can be remethylated to methionine. Whether the body needs cysteine or methionine will dictate which path homocysteine metabolism will take.
Production of cysteine from homocysteine requires two specific enzymes for which vitamin B-6 is an essential coenzyme. Without adequate vitamin B-6‚ homocysteine cannot be metabolized into cysteine. The body can also metabolize homocysteine by remethylating it to methionine. The primary route by which homocysteine is remethylated to methionine requires folate in the form of methyltetrahydrofolate as a methyl donor and vitamin B-12 (methylcobalamin) as a coenzyme. Methyltetrahydrofolate‚ or L-methylfolate‚ is synthesized in the body from dietary folic acid. However‚ L-methylfolate can be used directly by the body‚ without the need for folic acid conversion via the enzyme 5‚10-methylenetetrahydrofolate reductase (MTHFR). In certain populations‚ the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.
B vitamins‚ in particular folate‚ methylcobalamin‚ and vitamin B-6 are necessary for the body to metabolize homocysteine. A deficiency or suboptimal levels of any of these essential vitamins may cause plasma homocysteine levels to rise. Dietary surveys and epidemiological studies indicate that suboptimal levels of folate‚ vitamin B-12‚ and vitamin B-6 are common in many population groups. Elderly individuals‚ smokers‚ alcoholics‚ and medications users‚ including estrogens and popular medications for cholesterol and blood glucose control‚ are at risk for subclinical deficiencies of one or more of these B vitamins.
TMG‚ trimethylglycine‚ also known as betaine anhydrous‚ acts as a methyl donor in the methionine/homocysteine cycle. One route of homocysteine metabolism is by methylation to form methionine‚ using a methyl group from methylcobalamin or from trimethylglycine. Methionine is then converted to Sadenosylmethione (SAMe). Trimethylglycine is absorbed rapidly and has a high volume of distribution due to extensive distribution to tissues‚ including the kidneys and liver. When taken orally‚ trimethylglycine can support normal homocysteine levels.† Improvement in plasma homocysteine may be seen within a week‚ and steady state could be reached within a month.
Choline‚ also considered a B vitamin‚ can be oxidized to betaine which serves as a methyl donor to convert homocysteine to methionine. Dietary intake of choline might also support healthy homocysteine level.† The effect of dietary choline intake may be greatest on those with lower folate levels.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size 3 Vegetarian Capsules Servings Per Container 30
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).