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SAM-e 400 mg (Double Strength) 60 Tablets

Item # DRB1140
Regular Price: $71.99Our Price: $38.60
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SAM-e 400 mg (Double Strength) 60 Tablets
SAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 TabletsSAM-e 400 mg (Double Strength) 60 Tablets

Product Q & A
MFG # DRB-00252
UPC # 753950002524
Official Website: http://www.drbvitamins.com

Suitable for vegetarians

Science-based nutrition
Dietary supplement
Enhances mood and neural function
Promotes joint comfort and mobility
Supports liver health and detoxification

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S‚S form per serving‚ bar none.

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver‚ joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe
The manufacturing process of SAMe yields two forms‚ the S‚S and the R‚S isomers. The S‚S isomer is the active form that mediates biochemical activity in the human body‚ whereas the R‚S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S‚S form on the market.

SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans‚ essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement‚ and promote joint comfort.

SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters‚ which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine‚ supporting cognitive function.

SAMe and Liver Function
SAMe enhances liver synthesis of glutathione‚ an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.


Potent Promoter of Mood and Cognitive Health

After at least 18 controlled human trials‚ published over almost four decades‚ SAMe is clearly proven to promote healthy mood. The latest double-blind trial was published in 2010‚ and its findings were so impressive that the journal also published an editorial in praise of SAMe. This editorial attributed SAMe’s marked mood benefits to its diverse roles in brain metabolism.

SAMe is essential for the healthy metabolism of the major brain transmitters dopamine‚ serotonin‚ and norepinephrine. SAMe is also essential for the main metabolic pathway that makes PC (phosphatidylcholine)‚ a key cell membrane phospholipid for the nerve cell informational connections (synapses). Myelination—insulation of the nerve cell extensions to optimize their electrical conduction—also requires SAMe. And SAMe is also essential for the brain to produce melatonin‚ a hormone that regulates healthy sleep patterns.

Individuals who have mood difficulties often also have problems with memory and other cognitive functions. In a 2010 double-blind trial‚ SAMe supported cognitive health while promoting healthy mood. SAMe supports the metabolism of acetylcholine‚ a major nerve transmitter that is essential for attention‚ learning‚ and memory and for numerous other functions outside the brain. Even as SAMe ameliorates mood difficulties‚ SAMe also has improved energy levels‚ as found in two other double-blind trials. Optimal SAMe intakes for mood and cognitive support are 800-1600 mg per day‚ preferably as divided doses taken between meals.

Promotes Joint Comfort and Mobility

A minimum 14 controlled clinical trials prove SAMe is consistently effective for the support of joint comfort and mobility. In the longest trial‚ which lasted two years‚ 97 subjects received SAMe at 600 mg per day for the first two weeks‚ followed by 400 mg per day for the remaining period. SAMe continued to improve joint health over the entire course of this long trial‚ and was very well tolerated.

Most of the controlled trials for joint health used SAMe at 1200 mg per day. Researchers conducting these trials noted SAMe’s relative lack of adverse effects and its capacity to continue improving joint comfort and mobility over the entire period of the trial. A 2002 “meta-analysis” of pooled clinical trial data and a 2011 clinical review both concluded SAMe is a premier joint support nutrient.

The tissues of the working joint have a matrix of collagen and proteoglycans‚ large fibrous molecular complexes that give the joint structural stability. SAMe’s energized “active sulfur” group supports collagen and proteoglycan formation. SAMe’s active sulfur also supports the bio-synthesis of glutathione‚ cysteine‚ and taurine‚ key components of the joint’s antioxidant defenses (and of the liver and the body as a whole).

Protects and Supports the Liver and Intestine

The liver makes most of the body’s SAMe‚ and itself relies heavily on SAMe for its structural and functional integrity.22 The liver’s SAMe reserves are readily depleted by alcohol consumption‚ or by a variety of chemical toxins. In three human trials‚ supplementation with SAMe protected the liver against alcohol or other manmade toxins. These benefits of SAMe are most likely mediated by its support for the liver pathways that make glutathione and the other sulfur antioxidants.

Most of the liver’s glutathione comes ultimately from SAMe. The liver is the major organ wherein “active sulfur” from SAMe is fed into the vast web of sulfur pathways that make glutathione and the other sulfur antioxidants. These are at the hub of the liver’s considerable detoxication activity‚ and also provide its major defense against chemical damage. Functionally‚ glutathione status (and therefore liver health) is highly dependent on SAMe: experimental depletion of glutathione causes SAMe to be used up in replacing the glutathione‚ while repleting SAMe leads to restoration of glutathione reserves.

In addition to its multifaceted support for liver detoxication‚ SAMe also supports the liver’s bile secretion function‚ as reported in at least two clinical trials.

SAMe also helps keep the colon healthy. The colon normally houses bacteria that produce hydrogen sulfide‚ which is potentially toxic to biomolecules. The cells that line the colon use SAMe to detoxify hydrogen sulfide. In a clinical study‚ difficulties with colon function were linked to low blood levels of SAMe.

Methyl Source for Genetic‚ Epigenetic‚ and Other Vital Processes

Most of the body’s SAMe goes into “methyl transfer reactions‚” which make pervasive contributions to life processes. Methyl transfer enzymes use SAMe’s high-energy methyl group (“active methyl”) to produce thousands of biomolecules and subsequently to regulate their functional capacities.

Methyl is in our DNA. Active methyl from SAMe is used to make DNA‚ to make polyamine compounds that fold the DNA into its required shapes‚ to help repair damaged DNA‚ and to facilitate the “reading out” of DNA to make proteins. Methyl enzymes help ensure DNA is accurately converted into RNA and that in turn‚ this RNA is efficiently “translated” into proteins. SAMe’s active methyl is also used to fine-tune the shapes of proteins‚ to produce phospholipids that build cell membranes‚ to make hormones and chemical transmitters‚ and to manage miscellaneous major and minor biochemical tasks.

SAMe’s active methyl is also crucial for the regulation of gene activity using molecules that attach to the DNA (“epigenetic regulation"). Methyl enzymes selectively and precisely “tag” genes with methyl groups‚ to make these genes active or inactive according to the requirements for a particular cell or tissue. Methyl tagging regulates numerous other vital processes‚ including the functional specialization of cells‚ the coordination of the different cell types in tissues‚ the activation of detoxification enzymes‚ even the programming of reproduction and fetal development.

Disruption of the normal methyl patterning in human genes has been documented. Researchers found under-methylation of DNA in a human population (Greenland Inuit) exposed to high levels of pollutant chemicals. They suggested that as these environmental pollutants deplete glutathione they could also come to deplete SAMe. The consequent limitation of SAMe availability would limit availability of active methyl and account for the inadequate methyl tagging observed in this population. These researchers expressed considerable concern over the health implications of abnormal DNA methylation.

SAMe’s deoxyadenosyl group is also energy-activated and has considerable functional overlap with SAMe’s methyl transfer reactions. It has become clear that SAMe’s “active deoxy” is used by more than 2800 “Radical SAMe” enzymes‚ and gives SAMe even further importance for human health.

Essential For Energy Production by the Mitochondria

In two double-blind trials that involved subjects with energy complaints‚ SAMe significantly improved energy as well as mood. This health benefit from SAMe may be related to its roles as a key nutrient for our microscale energy generators‚ the mitochondria.

The mitochondria have their own semi-separate metabolic apparatus. They need SAMe to produce their own DNA‚ RNA‚ and proteins. They also rely on SAMe to make their own supplies of coenzyme Q10 and alpha lipoic acid‚ other nutrients crucial for energy generation and for their structural protection.

More than 90 percent of the body’s ATP is made in the mitochondria. They have intricate enzyme systems that use oxygen to “burn” our foods and thereby to make ATP. However‚ some of this oxygen escapes the mitochondria’s control and spawns potentially harmful oxygen free radicals. The mitochondria use glutathione as their core antioxidant for protection against these dangerous “sparks of metabolism.” To make sufficient glutathione the mitochondria must have sufficient SAMe. The multifaceted importance of SAMe for mitochondria helps explain how SAMe can enhance energy in the whole body.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Serving Size: 1 Tablet
Serving per container: 60 servings

Amount Per Serving %DV

S-Adenosyl Methionine 400 mg †
(from 800 mg of SAM-e tosylate disulfate)

Other Ingredients: Cellulose gel‚ methacrylic acid copolymer‚ compritol 888ATO‚ talc‚ triethyl citrate‚ titanium dioxide‚ magnesium stearate‚ mannitol‚ glycerol palmitostearate‚ silica‚ medium chain triglycerides‚ sodium starch glycolate‚ and iron oxide.

Contains nothing other than listed ingredients.

Does Not Contain: milk‚ egg‚ wheat‚ gluten‚ corn‚ soy‚ sugar‚ sweeteners‚ or preservatives.

Take 1 tablet daily away from food‚ or as directed by a health care professional. Do not chew or crush tablet.

Individuals diagnosed with bipolar disorder (“manic depression”) should avoid SAMe supplementation‚ as it may aggravate the manic phase.

SAMe should be taken between meals‚ at least one hour away from food. One or more tablets should be taken once or twice a day‚ to provide a minimum 200 mg to 800 mg per day of SAMe. Daily intakes up to 1600 mg may be useful‚ as directed by a competent healthcare professional. Avoid chewing or crushing the enteric-coated tablet‚ so that it can survive passage through the stomach.

SAM-e 400 mg (Double Strength) 60 Tablets
4 Stars based on 9 Review(s)
5/5 Stars
I would recommend this item to a friend.

helping my dog with high liver enzymes
April 22, 2014
Helps to bring my dogs liver enzymes into the lower high range
price for sam-e products make it cost prohibitive for me to take also although this brand is less expensive

Kapaa, HI
2/5 Stars

Didn't work for me
January 31, 2014
I tried these, and unfortunately they didn't work and are very expensive. But obviously with these types of things, everyone's body chemistry is different.
Very Expensive

NW Arkansas
1/5 Stars

Take the GI precaution seriously
January 10, 2014
Normailly, I don't have any GI issues with supplements and I take quite a few. I have osteoarthritis in my hip and have read that sam-e was fairly effective for osteoarthritis. The directions 'take away from food' has to be one of the worst written instructions on a supplement. What does that mean? An hour after eating, an hour before eating, 2 hours, 3 hours? I took it several hours after lunch for the first time. Major stomach ache. I re-read the box and noticed: May cause GI discomfort in a small percentage of people. I think they need to put that in BOLD. After reading reviews of sam-e and the GI problems that many people had, I read that the best time to take it was first thing in the morning with a full glass of water. They should think about including that in the instructions. That worked for the stomach ache. Not sure what to do about the GI issues, like loose stools. I've taken it for about 5 days and I'm debating whether to continue as I have not seen any benefit worth the discomfort and cost. It also seems to have the effect (like too much coffee) of feeling jittery. I was worried that it might keep me from sleeping, but that didn't prove to be an issue.
Not sure
GI issues, jitteriness

Coral Gables, FL
5/5 Stars
I would recommend this item to a friend.

Works a lot better
July 23, 2013
SAM-e works a lot better than regular SAM E from Doctor's best. Double strength is much more effective.

Apex, NC
4/5 Stars
I would recommend this item to a friend.

April 13, 2013
SAM-e has great quality and I've tried others but like this one the best. SAM-e helps me think clearer and keep my thoughts. Others have reported that they get anxious or experience insomnia, but I have not experienced any of that. I am taking SAM-e under the consult of my doctor.

Los Angeles, CA
5/5 Stars
I would recommend this item to a friend.

SAM-e has really helped me
March 20, 2013
I have been using SAM-e for years and it has really relieved the depression symptoms caused by meds for an autoimmune disease.
I've tried several brands and Doctor's Best has been the most consistent for me.
1. That it contains talc really concerns me. But every brand I've looked at or tried has at least objectionable ingredient. 2. SAM-e needs to be taken upon rising on an empty stomach. The suggested use instructions do not specify this.

Columbus, NJ
5/5 Stars
I would recommend this item to a friend.

January 24, 2013
Hubby has been taking SAM-e for a number of years. No adverse effects.
Easy to swallow.

5/5 Stars
I would recommend this item to a friend.

Has made a huge difference!
January 22, 2013
I started taking SAM-e for depression a few months ago. I can't believe the difference. Every day feels possible again and I have the energy I need to "do" my life. So glad to have found SAM-e.

5/5 Stars
I would recommend this item to a friend.

great mood enhancer
November 2, 2012
restores my mood, relieves anxiety. as a bonus it helps liver health
restores mood quickly
too pricey

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