Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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1 business day or less after the order is placed . You can now get real-time
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:
Methylation (contributing methyl groups to activate certain molecules) The synthesis of polyamines (for cell growth‚ gene expression‚ neuronal regeneration‚ etc.) Trans-sulfuration (synthesis of cysteine‚ glutathione‚ and other sulfate chemicals) SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones‚ nucleic acids‚ proteins‚ and phospholipids‚ catecholamines‚ and other neurotransmitters‚ such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine‚ dopamine‚ and serotonin‚ and also plays a role in other intracellular metabolic pathways. SAMe facilitates glutathione usage and maintains acetylcholine levels‚ which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.
SAMe levels may become depleted from sickness and age. Supplementation with the cofactors — folate‚ trimethylglycine (TMG or betaine)‚ vitamins B6 and B12‚ together with SAMe — appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine‚ which keeps cell membranes fluid‚ and is used in the brain to make the neurotransmitter acetylcholine.
In 2002‚ an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects. Since aging people often suffer joint discomfort and immobilization‚ SAMe addresses multiple problems people face as they grow older. In addition‚ SAMe has multiple mechanisms of action that are used throughout the body‚ especially in the liver‚ which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised‚ glutathione is depleted‚ which leads to free radical damage.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
This product contains NO milk‚ egg‚ fish‚ peanuts‚ crustacean shellfish (lobster‚ crab‚ shrimp)‚ soybeans‚ tree nuts‚ wheat‚ yeast‚ gluten‚ corn or rice. Contains NO sugar and no artificial sweeteners‚ flavors‚ colors‚ or preservatives.
Take one tablet two to three times daily in divided doses morning‚ midday‚ and late afternoon‚ or as recommended by a healthcare practitioner.
Take with co-factors vitamins B12‚ B6 and folic acid.
Taking this product with food may avoid gastrointestinal disturbance.
SAMe should not be taken by those diagnosed with bipolar disorder.
PureFormulas is your one-stop shop for health supplements, vitamins, minerals and other nutritional supplements. We carry thousands of products from a huge variety of prescreened manufacturers because our goal is to help you achieve optimal health, regardless of your age, lifestyle or location.
At PureFormulas, we hand pick every item in our inventory. We only work with the most reputable, trusted manufacturers of vitamins, minerals and nutritional supplements.
When you order from PureFormulas, you're getting access to our large inventory, the convenience of fast, free shipping, and the comfort of knowing your order is guaranteed authentic and fresh. Our dedicated team is here to make sure you have access to the best health supplements, vitamins and minerals and other nutritional supplements. Our friendly, efficient customer service is second-to-none, and we guarantee your satisfaction on every order you place through PureFormulas.
We invite you to browse our large selection of vitamins and minerals, nutritional supplements and other health supplements, and please contact us if you have any questions. We look forward to meeting your needs today!
Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).