Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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1 business day or less after the order is placed . You can now get real-time
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Sublingual Vitamin B12 tablets, provided by Douglas Laboratories, dissolve rapidly, releasing 2,500 mcg of pure vitamin B12.
Vitamin B12 is essential for normal energy metabolism of carbohydrates, fat and protein. As a cofactor for methylmalonyl-CoA mutase enzymes, vitamin B12 helps convert odd chain fatty acids and branched chain amino acids into succinyl-CoA, a common citric acid cycle intermediate. Vitamin B12 is also required for nucleic acid (DNA) synthesis, methionine synthesis from cysteine, and normal myelin synthesis in the nervous system. Along with vitamin B6 and folic acid, adequate levels of vitamin B12 are required to maintain normal plasma homocysteine levels. Elevated plasma homocysteine may be an independent risk factor for developing cardiovascular disease.
There are two distinct mechanisms for intestinal vitamin B12 absorption; receptor-mediated absorption and passive diffusion. In the first, vitamin B12 attaches to a salivary “R-binder” protein which transports it into the small intestine, where vitamin B12 is released. The vitamin then binds to “Intrinsic Factor” (IF), a glycoprotein normally produced by the gastric parietal cells. This vitamin B12-IF complex is carried down to the ileum, where it binds to mucosal receptors. Finally, the complex is absorbed and bound to serum vitamin B12-binding proteins. The second absorption mechanism, passive diffusion, does not require any carriers, such as B-binder or IF. Only about 1% of free vitamin B12 is passively absorbed, but this can be nutritionally significant with higher dietary vitamin B12 intakes. The elderly, HIV/AIDS patients, and strict vegetarians are often at risk for vitamin B12 deficiency, either due to low dietary intake or impaired absorption.
The receptor-mediated absorption pathway is subject to numerous genetic and pathologic defects which can severely impair normal vitamin B12 absorption. These defects include hereditary absence of IF production, gastric atrophy, gastrectomy, and small intestinal disorders affecting the ileum, such as gluten-induced enteropathy, regional enteritis, chronic diarrhea, and intestinal resection. Affected individuals depend almost exclusively on the passive diffusion pathway, which requires high dietary vitamin B12 intakes.
Vitamin B12 tablets may be a useful nutritional adjunct for individuals who wish to increase their intake of vitamin B12.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Each tablet contains:
Vitamin B12......................................................................... 2,500 mcg
One tablet daily, or as directed by physician. Tablet may be dissolved in mouth or swallowed whole.
PureFormulas is your one-stop shop for health supplements, vitamins, minerals and other nutritional supplements. We carry thousands of products from a huge variety of prescreened manufacturers because our goal is to help you achieve optimal health, regardless of your age, lifestyle or location.
At PureFormulas, we hand pick every item in our inventory. We only work with the most reputable, trusted manufacturers of vitamins, minerals and nutritional supplements.
When you order from PureFormulas, you're getting access to our large inventory, the convenience of fast, free shipping, and the comfort of knowing your order is guaranteed authentic and fresh. Our dedicated team is here to make sure you have access to the best health supplements, vitamins and minerals and other nutritional supplements. Our friendly, efficient customer service is second-to-none, and we guarantee your satisfaction on every order you place through PureFormulas.
We invite you to browse our large selection of vitamins and minerals, nutritional supplements and other health supplements, and please contact us if you have any questions. We look forward to meeting your needs today!
Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).