Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Vitamin D3 plays an integral role in bone metabolism‚ insulin function‚ innate and adaptive immunity and promotion of healthy inflammatory responses.
- Supports calcium homeostasis and maintenance of bone metabolism. - Promotes a healthy inflammation response. - Nutritionally supports normal insulin function. - Supports healthy immune function. - May help support healthy body weight.
Vitamin D is well known for its critical role in calcium homeostasis and regulation of bone metabolism‚ but recent evidence suggests that vitamin D may also play important roles in promotion of healthy inflammatory responses‚ insulin function‚ innate and adaptive immunity and even healthy body weight.
However‚ dietary sources of vitamin D are slim and most endogenous production of vitamin D occurs through the skin’s exposure to sunlight. Cholecalciferol‚ also known as vitamin D3‚ is formed from 7- dehydrocholesterol in the skin after exposure to UV light. Cholecalciferol is hydroxylated to calcidiol (25[OH] vitamin D) in the liver and then to calcitriol (1‚25[OH]2 vitamin D)‚ the active form of vitamin D‚ in the kidneys. However‚ many individuals are in areas of limited sunlight or use liberal amounts of sun protective factors (SPF) in sunscreen lotions‚ both of which limit vitamin D production in the skin and may necessitate vitamin D supplementation.
BONE HEALTH: Vitamin D contributes to bone health in several ways. For one‚ vitamin D inhibits parathyroid hormone activity which acts to maintain serum calcium and phosphate levels by inducing osteoclast activity. Osteoclasts break down skeletal bone to release calcium. Additionally‚ calcium absorption in the gut requires adequate vitamin D levels. Various studies have found an association between low vitamin D serum levels and joint disorders as well as decreased bone density. Risk for progression of these disorders increases substantially with low vitamin D intake and resultant decreased serum levels.
INFLAMMATION: Vitamin D promotes a healthy inflammation response. Recent studies analyzing the cellular events through which vitamin D balances inflammation look at vitamin D’s influence on lipopolysaccharide (LPS)-stimulated inflammatory responses. LPS induces proinflammatory cytokine production (e.g.‚ IL-6 and TNF-α) by activation of mitogen-activated protein kinases (MAPKs). While the proinflammatory cytokines are important for host defense‚ excessive production leads to unresolved inflammation. The MAPKs are inactivated by MAPK phosphatases (MKP)‚ leading to suppression of proinflammatory cytokine production. Vitamin D’s role in this chain of cellular events is in its activation and upregulation of the gene for MKP-1‚ thus inactivating MAPKs and balancing the production of proinflammatory cytokines.
BLOOD SUGAR: Low vitamin D levels are strongly associated with increased risk for conditions related to poor insulin function. Normal serum 25(OH) vitamin D concentrations have been shown to support normal insulin function and healthy blood sugar management. Vitamin D supports insulin sensitivity of of liver‚ fat and muscle cells and has been shown to support β-cell function in a healthy pancreas. Additionally‚ vitamin D helps balance the inflammatory cytokines that destroy β-cells in a healthy pancreas.
IMMUNE HEALTH: Vitamin D is involved in the development and function of both innate and adaptive immunity. Vitamin D receptors are found on macrophages‚ dendritic cells and T-cells. Calcitriol promotes macrophage differentiation and dendritic cell maturation. Macrophages play a key role in cell-mediated immunity by phagocytosing pathogens and cellular debris. Macrophages‚ along with dendritic cells‚ also interact with the adaptive immune system by acting as antigen-presenting cells (APCs). Vitamin D enhances and balances TH1 and TH2 immune responses.
BODY WEIGHT: New research is emerging on vitamin D’s role as a metabolic signal for storing fat. It has been proposed that physiologically‚ a low level of this “sunshine” vitamin may signal the body it is wintertime and thus may shift the body into a state of fat storage and weight gain.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Capsule Servings Per Container: 90
Amount Per Serving / % DV
Vitamin D3 (cholecalciferol) 1‚000 IU / 250 %
*Percent Daily Values are based on a 2‚000 calorie diet.
Other ingredients: Rice flour‚ cellulose.
Allergy Information - Product Details
As a dietary supplement‚ take 1-2 caps per day or as directed y your healthcare professional.
Keep tightly capped and store in a cool‚ dry place. Keep out of reach of children. If pregnant or breast feeding‚ consult your healthcare professional before use. Do not use if either tamper-evident seal is broken or missing.
PureFormulas is your one-stop shop for health supplements, vitamins, minerals and other nutritional supplements. We carry thousands of products from a huge variety of prescreened manufacturers because our goal is to help you achieve optimal health, regardless of your age, lifestyle or location.
At PureFormulas, we hand pick every item in our inventory. We only work with the most reputable, trusted manufacturers of vitamins, minerals and nutritional supplements.
When you order from PureFormulas, you're getting access to our large inventory, the convenience of fast, free shipping, and the comfort of knowing your order is guaranteed authentic and fresh. Our dedicated team is here to make sure you have access to the best health supplements, vitamins and minerals and other nutritional supplements. Our friendly, efficient customer service is second-to-none, and we guarantee your satisfaction on every order you place through PureFormulas.
We invite you to browse our large selection of vitamins and minerals, nutritional supplements and other health supplements, and please contact us if you have any questions. We look forward to meeting your needs today!
Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).