5-HTP 100 mg - 60 Veggie Capsules

by Doctor's Best
  • 4.4
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Quantity per Container: 60 Capsules
Item Number: DRB1042
Serving Size: 1 Capsule Servings per Container: 60
Price per Serving:  $0.19 Price per Unit*: $0.19 per Capsule
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
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5-HTP (5-hydroxy L-tryptophan) is a naturally occurring metabolite of the amino acid tryptophan. 5-HTP is converted in the brain to serotonin‚ a neurotransmitter substance found at the junctions (synapses) between neurons. 5-HTP helps maintain mental and emotional well-being and promotes healthy sleep. Best 5-HTP is based on science-based nutrition and contains a compound extracted from the seeds of the Griffonia simplicifolia plant.

Benefits of 5-HTP

5-HTP functions as the precursor for serotonin‚ a monoamine neurotransmitter found in the central nervous system (CNS) and some cells of the digestive tract. In the body‚ 5-HTP is formed by the addition of a hydroxyl group (–OH) to tryptophan‚ a reaction catalyzed by the enzyme tryptophan hydroxylase. This enzyme can be hindered by stress and conditions such as vitamin B6 deficiency‚ which is one reason B6 is included in this formula. Additionally‚ pyridoxal phosphate (vitamin B6) is necessary for 5-HTP to be converted to serotonin. Vitamin C participates in the conversion of tryptophan to 5-HTP and of tyrosine to norepinephrine‚ another important neurotransmitter.

Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors in the CNS. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors‚ including the person’s overall health and the competition between tryptophan and other amino acids for transport across the blood-brain barrier. Whereas tryptophan may be sidetracked into the production of niacin or protein‚ 5-HTP readily crosses the blood-brain barrier and becomes available for serotonin synthesis. Therefore‚ supplementation with 5-HTP is a more direct route to serotonin production.

In contrast to tryptophan‚ orally consumed 5-HTP is readily absorbed by the mucosal cells of the gastrointestinal tract‚ with up to 70% then appearing in the bloodstream. The implications of possibly altering serotonin in this manner are significant: serotonergic neurons (nerve cells stimulated by serotonin) regulate sleep‚ appetite‚ nociception (the perception of pain)‚ and aggressive behavior.

A synaptic serotonin deficit is hypothesized to be capable of a major adverse effect on your mood. Supplementation with 5-HTP may help balance your mood via an increase in serotonin synthesis. Best 5-HTP 100 mg may also promote relaxation and a feeling of calmness‚ which is necessary in today’s world. Additionally‚ pyridoxine deficiency may be related to fatigue.

Some also believe that 5-HTP can support satiety and healthy eating patterns. While serotonin is renowned for its functioning in the brain‚ 95% of serotonin is actually found in the gastrointestinal tract. Accordingly‚ serotonin is deeply involved in gut physiology‚ including visceral perception and weight maintenance. For example‚ feeling less stressed may lessen emotional eating.

Studies have shown that 5-HTP can positively influence the quality of sleep by increasing restorative REM (rapid eye movement) sleep. This can leave you feeling more energetic and less irritable during the day.

Finally‚ Doctor’s Best’s Best 5-HTP may serve as a potent scavenger of potentially harmful free radicals. Compounds such as vitamin E and flavonoids derive their free-radical quenching ability from their hydroxyl groups (–OH)‚ which donate electrons to oxidants. 5-HTP is formed from tryptophan by the addition of an –OH group‚ which gives 5-HTP its antioxidant properties; this is in contrast to tryptophan‚ which is sensitive to oxidation. The effectiveness of 5-HTP in preventing lipid and protein oxidation is believed to support liver health‚ similar to vitamin C.

Each bottle of Best 5-HTP 100 mg by Doctor’s Best contains 60 vegetarian capsules.

For over two decades‚ Doctor's Best has provided a wide variety of nutritional supplements. All Doctor's Best products are made with the highest-quality raw ingredients available on the market. Its formulations are science-based and tested for effectiveness and safety.



These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # DRB-00077
  • UPC # 753950000773
Official Website: http://www.drbvitamins.com

Serving Size: 1 Veggie Capsule
Servings Per Container: 60

Amount Per Serving / % DV

5-Hydroxy L-Tryptophan 100mg / †

†Daily Value not established.

Other Ingredients: Modified cellulose (vegetarian capsule)‚ microcrystalline cellulose‚ silicon dioxide.

Non-GMO / Gluten-Free / Soy-Free / Vegan / Vegetarian.

Take 1 capsule daily‚ with or without food‚ or as recommended by a nutritionally informed physician.

Not to be used when taking MAO inhibitors‚ selective serotonin reuptake inhibitors (SSRIs)‚ or other antidepressant medications. It should also not be used by individuals taking any of the category of medications known as "triptans".

Keep out of reach of children.

Store in a cool‚ dry place.

  • Dairy Free
  • Gluten Free
  • GMO Free
  • Soy Free
  • Vegan
  • Vegetarian

Ratings and Reviews

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  • 4.4
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4 48
  • 48 Reviews
    • Verified Buyer

      Good product

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      from EDGEWOOD MD on 5/04/2020
      First time I've ordered and they seem to be working well. I've suffered from depression & anxiety for years and 5HTP works great for managing the symptoms. These compare well to Nature Made, Nature's Bounty, and Sundown which is what I usually buy.

      Pros

      Price is cheaper than what I usually buy. They seem to work just as well as other brands.

      Cons

      N/A
      I would recommend this item to a friend.
    • Verified Buyer

      Good price, and works great

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      from CHEVY CHASE MD on 4/17/2020
      I take this with tyrosine on an empty stomach, and puts a pep in my step!

      Pros

      Price, efficacy.

      Cons

      The pills are so tiny. Sometimes I lose them.
      I would recommend this item to a friend.
    • Verified Buyer

      Taking for sleep

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      from RIDGEFIELD WA on 1/07/2020
      Tried taking at night for sleep
      I would recommend this item to a friend.
    • Verified Buyer

      great for the money

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      from La Mesa CA on 4/06/2019
      This product is excellent. It helps me to sleep at night

      Pros

      superb

      Cons

      I like it
      I would recommend this item to a friend.
    • Verified Buyer

      Not sure about this

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      from SPOKANE VALLEY WA on 12/26/2017
      I haven't noticed positive changes in mood or sleep from 5-HTP 100 mg by Doctor's Best. I have started to forget to take it everyday. I've heard it takes a while to work maybe I'm impatient but I have lost faith in this brand. I used to love the brand but not so much anymore.
    • Verified Buyer

      Love it

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      from Kauai HI on 11/03/2017
      Best 5-HTP 100mg by Doctor's Best works amazingly well to ease anxiety and depression. It can make you feel sleepy so make sure to use it at night and if you use it during the day just make sure to have tea or something to energize you if you need that. Otherwise this is a must have if you are needing something and don't want to go on Prozac or something like that. I would take this along with Taurine and perhaps holy basil. But you don't need those other things, it's just helpful. This works great all on its own.

      Pros

      It works for anxiety and depression really well.

      Cons

      Makes you a bit sleepy so take at night.
      I would recommend this item to a friend.
    • Verified Buyer

      Better sleep - less anxiety.

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      from Kentucky on 3/26/2017
      I was very happy with my improved sleep from Best 5 HTP 100 mg by Doctor's Best. I feel somewhat less anxiety as well... very subtle.
      I would recommend this item to a friend.
    • Best 5 HTP Veggie Capsules

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      from North Carolina on 1/29/2017
      I am a 65 year old women and I do not eat balanced meals like I should. I feel this Best 5-HTP 100 mg by Doctor's Best supplies me with my daily requirements! I feel so much better about my overall health now!

      Pros

      I like just taking one capsule a day.

      Cons

      No dislikes
      I would recommend this item to a friend.
      0 of 2 people found the following review helpful.
    • Verified Buyer

      Good Product for the price

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      from boston on 11/01/2016
      The price to quality ratio is pretty good for Best 5-HTP 100 mg by Doctor's Best.

      Pros

      Cost to effect ratio, Veggie Caps, and Dosage.

      Cons

      None
      I would recommend this item to a friend.
    • Verified Buyer

      Helps with sleep

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      from Lake Tahoe on 9/04/2016
      I found Best 5-HTP 100 mg by Doctor's Best effective when I was experiencing low mood and difficulty falling asleep. I have heard that 5-HTP can be a little hard on your liver, so if you have any concerns with that, you may want to consult your doctor before using.
      I would recommend this item to a friend.
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Customer Questions and Answers

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  • Question:
    does this product D35 is it cholecalciferd and does it contain 
    G Walker on 2/24/2016 Answer:
    • Hi there! Thank you for your question. No this product does not contain any dairy, fish, egg, shellfish, nuts, wheat, gluten, soy, sugar, yeast or artificial color. :)
      PureFormulas on 2/24/2016

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