Calcium D-Glucarate - 90 Capsules

by Thorne Research
    4.8
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"I take Calcium D-Glucarate by Thorne Research daily as prescribed."  Read all reviews

Quantity per Container: 90 Capsules
Item Number: TR1037
Serving Size: 1 Capsule Servings per Container: 90
Price per Serving:  0.49 Price per Unit*: $0.49 per Capsule
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
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    Calcium D-Glucarate (CDG) has been shown to promote liver detoxification by preventing recycling of undesirable hormones and environmental toxins. It also helps maintain normal cholesterol levels.


    Calcium D-Glucarate (CDG) is produced naturally in small amounts by humans. CDG supplementation has been shown to prevent the recycling of hormones and undesirable environmental toxins‚ thereby promoting liver detoxification and the excretion of these potentially detrimental substances. Other applications of CDG supplementation include the maintenance of already normal cholesterol levels and facilitating healthy hormone metabolism.

    How does it work?
    Glucuronidation is the liver's normal process of attaching a glucuronic acid molecule to potentially harmful substances to detoxify and eliminate them from the body. During phase II liver detoxification‚ certain hormones and various fat-soluble toxins will undergo glucuronidation and be excreted through the bile or urine. Calcium D-Glucarate helps this elimination process to occur uninterrupted.

    The more detailed version: Upon ingestion and exposure to the acidic environment of the stomach‚ Calcium D-Glucarate is metabolized to form D-glucaric acid. D-glucaric acid is further metabolized in the gastrointestinal tract into three compounds that exist in equilibrium and are comprised of approximately 40-percent D-glucaric acid‚ 30-percent D-glucaro-1‚4-lactone‚ and 30-percent D-glucaro-6‚3-lactone. These compounds are then transported to the blood and various internal organs‚ and subsequently excreted in the urine and bile. Although D-glucaro-1‚4-lactone is apparently the most pharmacologically active of the three‚ it is not commercially available. Also‚ Calcium D-Glucarate administration results in longer inhibition of beta-glucuronidase (five hours versus one hour) than does D-glucaro-1‚4-lactone‚ so it is the compound used.

    Calcium D-Glucarate's detoxifying and chemopreventive properties are attributable to its ability to increase glucuronidation‚ and the accompanying excretion of harmful compounds. It does so by inhibiting the enzyme beta-glucuronidase. During Phase II detoxification‚ hormones and various undesirable lipid-soluble toxins are bound to glucuronic acid in the liver (glucuronidation) and excreted through the biliary tract; however‚ beta-glucuronidase can unbind these toxins‚ which makes it possible for them to be reabsorbed rather than excreted. D-glucaro-1‚4-lactone is the metabolite that most inhibits the activity of beta-glucuronidase‚ thereby increasing the excretion of toxic compounds and decreasing the activity of harmful substances that are most active in their unbound state. Inhibition of beta-glucuronidase by Calcium D-Glucarate metabolites ultimately results in potentially decreasing the risk of toxicity.

    In addition‚ by reducing the activity of beta-glucuronidase and the viability of harmful intestinal bacteria‚ the salts of D-glucaric acid have been shown to enhance enterohepatic circulation and reduce cholesterol synthesis‚ thus resulting in maintenance of healthy cholesterol levels.



    These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.


  • MFG # M280
  • UPC # 693749280026
Official Website: http://www.thorne.com

Serving Size: One Capsule
Servings Per Container: 90

One Capsule Contains / %DV

Calcium 62 mg / 4%
Calcium D-Glucarate 500 mg / *

*Daily Value (DV) not established.

Other Ingredients: Hypromellose (derived from cellulose) capsule‚ Leucine.

Gluten Free.


Take 1 capsule three times daily or as recommended by your health professional.


ALLERGY WARNING S
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY WARNING
If pregnant‚ consult your health professional before using this product.

INTERACTIONS
There are no known adverse interactions or contraindications at publication date.

TAMPER EVIDENT
Use only if bottle is sealed. Store tightly sealed in a cool‚ dry place.


  • Egg Free
  • Gluten Free
  • High Fructose Corn Syrup Free
  • Nut Free
  • Peanut Free

Ratings and Reviews

Write a Review
    4.8
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  • Average Rating: 4.8 out of 5 stars
5 13
13 Reviews
  • Happy!

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    from TX on 4/07/2016
    Calcium D Glucarate by Thorne Research works well, I saw my zits are reduced and less skin irritations

    Pros

    Detox, helps skin clearer.

    Cons

    I would recommend this item to a friend.
  • High quality calcium!

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    from TX on 3/08/2016
    Calcium D Glucarate by Thorne Research has good ingredients and the dosage is just enough for my mid age. It helps make my nail stronger, less hair fallen.
    I would recommend this item to a friend.
  • Detoxing Calcium D-Glucarate

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    from MA on 12/24/2014
    This brand was recommended by my primary care doc to help with my intolerance to many supplements. So far I haven't noticed any improvements but I'm hoping I tolerate this hyper-allergenic formula.

    Pros

    hyper allergenic, easy to take

    Cons

    cost
    I would recommend this item to a friend.
  • Verified Buyer

    Great!

      5
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    from SC on 10/19/2014
    I use Calcium D-Glucarate by Thorne Research in conjunction with pure encapsulations dim detox. These work great to treat excess estrogen, clear hormonal acne and just help my overall wellbeing. I take 1 in the morning and 1 in the evening.
    I would recommend this item to a friend.
    2 of 2 people found the following review helpful.
  • Verified Buyer

    Fantastic Product!

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    from Suwanee, GA on 3/26/2014
    I used this product in combination with Thornes Indole 3 Carbinol to remove excess estrogen from my body. It has worked great. It is also easy to swallow and does not have a taste so you can take it alone or with a meal. I highly recommend it!
    I would recommend this item to a friend.
    1 of 1 people found the following review helpful.
  • Verified Buyer

    Works Great!

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    from PA on 3/24/2014
    Ive used this for my daughter on the recommendation of a nutritionist to pull the excess estrogen from her body. Weve used it for about a year and a half now and it seems to be working very well.
    I would recommend this item to a friend.
  • Verified Buyer

    Taking for Detoxification

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    from Pompano Beach, FL on 1/31/2014
    Ive read several articles about this being a potent detoxifier for the liver. I sue this for helping my Liver metabolize estrogen as well as other metabolic junk that accumulate over time from other chemicals that sneak in from the environment (cosmetics cleaning supplies carpeting paint synthetic fabrics etc). How well its working?...cant really tell. I just trust that it doing my liver good as it is said to do.
    I would recommend this item to a friend.
  • Verified Buyer

    Preventing breast lumps for 20 years

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    from Sacramento, Ca on 3/01/2013
    All the females of our family have been plagued with "boobie" issues. Swollen and sore ducts are a regular thing in my life. However when I take Calcium D-Glucarate it goes away within three days. Must take while eating food. You need bile to activate it to its full potential. Take good care!
    I would recommend this item to a friend.
  • Verified Buyer

    Excellent Product

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    from Arizona on 11/13/2012
    When nothing else worked to help regulate menstrual bleeding Calcium D-Glucarate finally did. It takes being under a doctors care to get the right amount but we finally found the right dosage that worked for me.
    I would recommend this item to a friend.
  • Excellent Product

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    from FL on 7/31/2012
    Calcium D Glucurate helps with estrogen dominance. Gets rid of the excess and bad estrogens in my system and other toxins also. Reduces painful breast swelling and stomach bloating. I take 3000 mg per day need to work up to this dosage start out slow as too much too soon can produce a detox/die off feeling. Thorne is excellent quality and worth the price. I dont get the same relief from less expensive calcium glucurate that has fillers and such.

    Pros

    Helps with estrogen dominance.

    Cons

    Nothing excellent product.
    I would recommend this item to a friend.
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If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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