Double-Strength SAM-e 400 mg - 60 Enteric Coated Tablets

by Doctor's Best
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"SAM-e has great quality and Ive tried others but like this one the best. SAM-e h..."  Read all reviews

Item Number: DRB1140
Serving Size: 1 Tablet Servings per Container: 60
Price per Serving:  $0.73 Price per Unit*: $0.73 per Tablet
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
29 In Stock.

This item will ship on Monday before 5PM EST.

Regular Price:  $74.99 $ $43.58
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Doctor’s Best SAM-e is proven to enhance mood and promote cognitive health. It is essential for the healthy metabolism of the major brain transmitters’ dopamine‚ serotonin and norepinephrine. In addition‚ SAM-e promotes joint comfort and mobility and supports liver health and detoxification. SAM-e effectiveness has been published in 18 controlled human trials published over 40 years. Doctor’s Best SAM-e uses pharmaceutical grade materials. SAM-e is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. SAM-e optimized for potency‚ stability‚ and to survive the stomach acid and reach the intestine (where it is absorbed). Effectiveness of SAM-e has been backed by at least 18 controlled human trials published over almost four decades.



These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # DRB-00252
  • UPC # 753950002524
Official Website: http://www.drbvitamins.com

Serving Size: 1 Tablet
Servings Per Container: 60

Amount Per Serving / % DV

S-Adenosyl Methionine (From 800mg of SAM-e tosylate disulfate) 400mg / †

†Daily Value not established.

Other Ingredients: Microcrystalline cellulose‚ magnesium hydroxide‚ stearic acid‚ calcium chloride anhydrous‚ magnesium stearate‚ colloidal silica anhydrous‚ calcium oxide‚ magnesium silicate‚ natural food glaze‚ arginine base‚ glycerol‚ sodium alginate.

Gluten-Free / Soy-Free / Vegan / Vegetarian.

Take 1 tablet daily between meals‚ or as recommended by a nutritionally informed physician.

Do not chew or crush tablet.

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.

Individuals diagnosed with bipolar disease or manic depression should avid supplementing with SAMe.

Do not use if pregnant or nursing.

Store in a cool‚ dry place.

Notice: May cause gastrointestinal discomfort in a small percentage of people.

  • Dairy Free
  • Gluten Free
  • Soy Free
  • Vegan
  • Vegetarian

Ratings and Reviews

Write a Review
  • 4.5
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4 17
  • 17 Reviews
    • Verified Buyer

      Sam-e 400mg

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      from NORTH CAROLINA on 12/22/2018
      This SAM-e 400 mg (Double Strength) by Doctor's Best is very helpful for some for depression. It's something anyone should at least try before seeking prescriptions. It's worth the try!

      Pros

      It helps with depression.

      Cons

      It may not work for serious conditions.
      I would recommend this item to a friend.
    • Verified Buyer

      Incredible results!

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      from Texas on 7/07/2016
      I've been taking SAM-e by Doctor's Best for about 2 months now and I have felt a big change (Dr. recommendation). No more sadness or depression and better focus.

      Pros

      It's gentle with my stomach and enhances mood really fast.

      Cons

      The size of the pills.
      I would recommend this item to a friend.
    • Verified Buyer

      Very effective!

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      from oregon on 7/29/2015
      Adult child has anxiety and panic attacks. SAM-e by Doctor's Best has been helpful.

      Pros

      Effective.

      Cons

      I would recommend this item to a friend.
    • Verified Buyer

      I love it!

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      from connecticut on 3/18/2015
      I enjoy taking SAM-e by Doctor's Best and I love the way it helps me!

      Pros

      The way it makes me feel!

      Cons

      I would recommend this item to a friend.
    • Great Mood Support

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      from United States of America on 1/24/2015
      I take 800 mg. in the morning for mood support along with Gaia Herbs St. John's Wort. I did not notice a difference when taking only 1 pill (i.e. 400 mg) a day but I got mood improvement from taking 2 pills.

      Pros

      Like how the pills are packaged.

      Cons

      Expensive and the list of additives are unrecognizable ingredients are quite long! Wish there was a SAM-e product out there without all the additives.
      I would recommend this item to a friend.
    • GREAT VALUE!!

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      from Virginia on 12/11/2014
      My husband takes the Sam-E  by Doctor's Best for liver support, ( prescribed by his Dr) which has been excellent. He also reaps the benefit of it being a mood elevator. It also helps with joint discomfort and better joint function. He has had a very good experience with it. Just remeber, if you tend to be bi-polar, this is NOT for you!! see the warnings about SAM E .

      Pros

      Excellent value and wonderful product.

      Cons

      None.
      I would recommend this item to a friend.
    • SAM-e

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      from Birdsboro,PA on 11/21/2014
      Taking Doctor's Best SAM-e has helped keep my energy levels up.

      Pros

      Tablets are individually packaged. This makes it easy for taking them with you and keeping them fresh.

      Cons

      Nothing.
      I would recommend this item to a friend.
    • Verified Buyer

      helping my dog with high liver enzymes

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      from chig on 4/22/2014
      Helps to bring my dogs liver enzymes into the lower high range

      Pros

      Cons

      price for sam-e products make it cost prohibitive for me to take also although this brand is less expensive
      I would recommend this item to a friend.
    • Verified Buyer

      Didnt work for me

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      from Kapaa, HI on 1/31/2014
      I tried these and unfortunately they didnt work and are very expensive. But obviously with these types of things everyones body chemistry is different.

      Pros

      Cons

      Very Expensive
    • Verified Buyer

      Take the GI precaution seriously

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      from NW Arkansas on 1/10/2014
      Normailly I dont have any GI issues with supplements and I take quite a few. I have osteoarthritis in my hip and have read that sam-e was fairly effective for osteoarthritis. The directions take away from food has to be one of the worst written instructions on a supplement. What does that mean? An hour after eating an hour before eating 2 hours 3 hours? I took it several hours after lunch for the first time. Major stomach ache. I re-read the box and noticed: May cause GI discomfort in a small percentage of people. I think they need to put that in BOLD. After reading reviews of sam-e and the GI problems that many people had I read that the best time to take it was first thing in the morning with a full glass of water. They should think about including that in the instructions. That worked for the stomach ache. Not sure what to do about the GI issues like loose stools. Ive taken it for about 5 days and Im debating whether to continue as I have not seen any benefit worth the discomfort and cost. It also seems to have the effect (like too much coffee) of feeling jittery. I was worried that it might keep me from sleeping but that didnt prove to be an issue.

      Pros

      Not sure

      Cons

      GI issues jitteriness
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If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008

If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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